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  1. Post-Myocardial Infarction The VALsartan In Acute myocardial iNfarcTion trial (valiant) was a randomized, controlled, multinational, double-blind study in 14,703 patients with acute myocardial infarction and either heart failure (signs, symptoms or radiological evidence) or left ventricular systolic dysfunction (ejection fraction. Warning, fetal toxicity, when pregnancy is detected, discontinue Diovan as soon as possible.